Electromembrane extraction using deep eutectic solvents as the liquid membrane

In this work, we investigated for the first time hydrophobic deep eutectic solvents (DES) as supported liquid membrane (SLM) electromembrane extraction (EME). Camphor, coumarin, DL-menthol, and thymol were used non-ionic DES components. Different DESs compositions tested, to study systematically importance of hydrogen bonding dispersion/aromatic interactions during mass transfer across SLM. Unexpectedly, mixtures coumarin highly efficient SLMs, provided exhaustive or near-exhaustive non-polar bases, acids, polar bases. SLMs with such performance both bases in a large polarity window, are not found current literature. The aromatic, very strong donors, moderately acceptors. Aromatic (π type) apparently important while dominant acids. EME six basic drugs from plasma, mixture SLM, combined UHPLC-MS/MS analysis, was evaluated test potential analytical applications. Plasma diluted 1:1 phosphate buffer pH 2.0. Calibration curves linear therapeutic ranges (0.970 < R2 0.999), recoveries ranged between 47 93%, repeatability within 1.6–10.7% RSD. clean-up efficiency excellent no matrix effects plasma seen. Presence trace levels acceptor phase however cause some ion enhancement. Based on foresee more research use EME.